Featured Publications

Predictors of Intradialytic Symptoms: An Analysis of Data From the Hemodialysis Study

Most patients receiving hemodialysis experience adverse symptoms associated with decreased quality of life. We analyzed data from a previous large study and determined ways to predict upcoming adverse symptoms. This will allow future researchers to use these predictors when studying ways to prevent adverse symptoms.

A Randomized control trial of two Dialysate sodium concentrations in hospitalized hemodialysis patients

Excessively low blood pressure during hemodialysis is associated with adverse outcomes. We performed a randomized control trial with 139 patients to determine if higher versus lower concentrations of dialysate sodium reduced the magnitude of blood pressure decline during hemodialysis. Although we did not find significant differences in the primary analyses , there were no differences in adverse effects between arms. Furthermore, in post-hoc adjusted analyses accounting for baseline imbalances there was a suggestion of less BP decline in patients receiving higher dialysate sodium.

Hypertonic Mannitol for the Prevention of Intradialytic Hypotension: A Randomized Controlled Trial

Low blood pressure during dialysis affects patients everyday causing uncomfortable and potentially dangerous adverse effects. Our team tested a medication on patients undergoing dialysis to see if it would help reduce the number of times patients had these symptoms. The results allowed us to understand its future potential towards improving the lives of patients on dialysis and setting up future studies for further analysis.

All Publications

2024

Mc Causland FR, Charytan DM. To Cool the Dialysate or Not? Question Answered? Clin J Am Soc Nephrol. 2024 Jan 1;19(1):119-121. doi: 10.2215/CJN.0000000000000227. Epub 2023 Jun 14. PMID: 37314774; PMCID: PMC10843191. View in PubMed

Andersson C, Hansen D, Sørensen SS, McGrath M, McCausland FR, Torp-Pedersen C, Schou M, Køber L, Pfeffer MA. Long-term cardiovascular events, graft failure, and mortality in kidney transplant recipients. Eur J Intern Med. 2024 Mar;121:109-113. doi: 10.1016/j.ejim.2023.10.026. Epub 2023 Oct 29. PMID: 37903704. View in PubMed

Mc Causland FR, Claggett BL, Vaduganathan M, Desai A, Jhund P, Vardeny O, Fang JC, de Boer RA, Docherty KF, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Saraiva JFK, McGrath MM, Shah SJ, Verma S, Langkilde AM, Petersson M, McMurray JJV, Solomon SD. Decline in Estimated Glomerular Filtration Rate After Dapagliflozin in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Secondary Analysis of the DELIVER Randomized Clinical Trial. JAMA Cardiol. 2024 Feb 1;9(2):144-152. doi: 10.1001/jamacardio.2023.4664. Erratum in: JAMA Cardiol. 2024 Jul 1;9(7):674. doi: 10.1001/jamacardio.2024.1234. PMID: 37952176; PMCID: PMC10641768. View in PubMed

Elsayed E, Farag YMK, Ravi KS, Chertow GM, Mc Causland FR. Association of Bioimpedance Parameters with Increases in Blood Pressure during Hemodialysis. Clin J Am Soc Nephrol. 2024 Mar 1;19(3):329-335. doi: 10.2215/CJN.0000000000000356. Epub 2023 Nov 16. PMID: 37971865; PMCID: PMC10937019. View in PubMed

Vardeny O, Desai AS, Jhund PS, Fang JC, Claggett B, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez FA, Shah SJ, Mc Causland FR, Petrie MC, Vaduganathan M, McMurray JJV, Solomon SD. Dapagliflozin and Mode of Death in Heart Failure With Improved Ejection Fraction: A Post Hoc Analysis of the DELIVER Trial. JAMA Cardiol. 2024 Mar 1;9(3):283-289. doi: 10.1001/jamacardio.2023.5318. PMID: 38265835; PMCID: PMC10809142. View in PubMed

Chatur S, Neuen BL, Claggett BL, Beldhuis IE, Mc Causland FR, Desai AS, Rouleau JL, Zile MR, Lefkowitz MP, Packer M, McMurray JJV, Solomon SD, Vaduganathan M. Effects of Sacubitril/Valsartan Across the Spectrum of Renal Impairment in Patients With Heart Failure. J Am Coll Cardiol. 2024 Jun 4;83(22):2148-2159. doi: 10.1016/j.jacc.2024.03.392. Epub 2024 Apr 6. PMID: 38588927. View in PubMed

Elsayed E, Farag YMK, Ravi KS, Chertow GM, Mc Causland FR. Association of Changes in Vector Length with Changes in Left Ventricular Mass among Patients on Maintenance Hemodialysis: A Secondary Analysis of the Frequent Hemodialysis Network Daily Trial. Kidney360. 2024 Jun 1;5(6):870-876. doi: 10.34067/KID.0000000000000443. Epub 2024 Apr 24. PMID: 38656312; PMCID: PMC11219120. View in PubMed

Kondo T, Jhund PS, Gasparyan SB, Yang M, Claggett BL, McCausland FR, Tolomeo P, Vadagunathan M, Heerspink HJL, Solomon SD, McMurray JJV. A hierarchical kidney outcome using win statistics in patients with heart failure from the DAPA-HF and DELIVER trials. Nat Med. 2024 May;30(5):1432-1439. doi: 10.1038/s41591-024-02941-8. Epub 2024 May 6. PMID: 38710952; PMCID: PMC11108780. View in PubMed

Ostrominski JW, Claggett BL, Miao ZM, Mc Causland FR, Anand IS, Desai AS, Jhund PS, Lam CSP, Pfeffer MA, Pitt B, Zannad F, Zile MR, Bomfim Wirtz A, Lay-Flurrie J, Viswanathan P, McMurray JJV, Solomon SD, Vaduganathan M. Cardiovascular-Kidney-Metabolic Overlap in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Trial-Level Analysis. J Am Coll Cardiol. 2024 Jul 9;84(2):223-228. doi: 10.1016/j.jacc.2024.05.005. Epub 2024 May 12. PMID: 38744407. View in PubMed

Moloney BM, Chertow GM, Mc Causland FR. Association of Diabetes with Changes in Blood Pressure during Hemodialysis: A Secondary Analysis of the Frequent Hemodialysis Network Daily Trial. Am J Nephrol. 2024;55(4):409-416. doi: 10.1159/000539451. Epub 2024 May 24. PMID: 38781949; PMCID: PMC11305924. View in PubMed

Chatur S, Beldhuis IE, Claggett BL, McCausland FR, Neuen BL, Desai AS, Rouleau JL, Zile MR, Packer M, Pfeffer MA, Lefkowitz MP, McMurray JJV, Solomon SD, Vaduganathan M. Sacubitril/Valsartan in Patients With Heart Failure and Deterioration in eGFR to <30 mL/min/1.73 m². JACC Heart Fail. 2024 May 21:S2213-1779(24)00317-2. doi: 10.1016/j.jchf.2024.03.014. Epub ahead of print. PMID: 38842957. View in PubMed

Lefranc Torres A, Correa S, Mc Causland FR. Association of Calcium Channel Blocker Use With Intradialytic Hypotension in Maintenance Hemodialysis. Kidney Int Rep. 2024 Mar 27;9(6):1758-1764. doi: 10.1016/j.ekir.2024.03.024. PMID: 38899200; PMCID: PMC11184255. View in PubMed

Mc Causland FR, McGrath MM, Claggett BL, Barkoudah E, East C, Fernandez A, Jering KS, Lewis EF, McMurray JJV, Mody FV, Solomon SD, Tokmakova M, van der Meer P, Zhou Y, Pfeffer MA. Acute changes in kidney function and outcomes following an acute myocardial infarction: Insights from PARADISE-MI. Eur J Heart Fail. 2024 Jul 26. doi: 10.1002/ejhf.3386. Epub ahead of print. PMID: 39056455. View in PubMed

Ravi KS, Tumlin JA, Roy-Chaudhury P, Koplan BA, Costea AI, Kher V, Williamson D, McClure CK, Charytan DM, Mc Causland FR; MiD investigators and Committees. Association of Dialysate Bicarbonate with Arrhythmia in the Monitoring in Dialysis (MiD) Study. Kidney360. 2024 Aug 6. doi: 10.34067/KID.0000000000000537. Epub ahead of print. PMID: 39116279. View in PubMed

Lu H, Chatur S, Lee S, Inciardi RM, Abanda M, Mc Causland FR, Kalayci A, Taheri KK, Shah AM, Cikes M, Claggett BL, Prasad N, Lam CSP, O’Meara E, Wang X, McMurray JJV, Pfeffer MA, Hegde SM, Solomon SD, Skali H. Relationship Between Cardiac Structure and Function With Renal Function Trajectory and Outcomes in Patients With Heart Failure: Insights From the PARAGON-HF Trial. Circ Heart Fail. 2024 Aug 30:e011942. doi: 10.1161/CIRCHEARTFAILURE.124.011942. Epub ahead of print. PMID: 39212045. View in PubMed

Neuen BL, Ostrominski JW, Claggett B, Beldhuis IE, Chatur S, McCausland FR, Badve SV, Arnott C, Heerspink HJL, Jun M, Falster M, de Oliveira Costa J, Pollock C, Jardine MJ, Mahaffey KW, Perkovic V, Solomon SD, Vaduganathan M. Bidirectional Relationship Between Kidney Disease Progression and Cardiovascular Events in Type 2 Diabetes. J Am Coll Cardiol. 2024 Aug 26:S0735-1097(24)08155-5. doi: 10.1016/j.jacc.2024.08.006. Epub ahead of print. PMID: 39217558. View in PubMed

Neuen BL, Vaduganathan M, Claggett BL, Beldhuis I, Myhre P, Desai AS, Skali H, Mc Causland FR, McGrath M, Anand I, Zile MR, Pfeffer MA, McMurray JJV, Solomon SD. Natriuretic Peptides, Kidney Function, and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2024 Aug 31:S2213-1779(24)00610-3. doi: 10.1016/j.jchf.2024.08.009. Epub ahead of print. PMID: 39365237. View in PubMed

2023

Mc Causland FR, Claggett BL, Vaduganathan M, Desai AS, Jhund P, de Boer RA, Docherty K, Fang J, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Saraiva JFK, McGrath MM, Shah SJ, Verma S, Langkilde AM, Petersson M, McMurray JJV, Solomon SD. Dapagliflozin and Kidney Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the DELIVER Randomized Clinical Trial. JAMA Cardiol. 2023 Jan 1;8(1):56-65. doi: 10.1001/jamacardio.2022.4210. PMID: 36326604; PMCID: PMC9634592. View in PubMed

Singh AK, McCausland FR, Claggett BL, Wanner C, Wiecek A, Atkins MB, Carroll K, Perkovic V, McMurray JJV, Wittes J, Snapinn S, Blackorby A, Meadowcroft A, Barker T, DiMino T, Mallett S, Cobitz AR, Solomon SD. Analysis of on-treatment cancer safety events with daprodustat versus conventional erythropoiesis-stimulating agents-post hoc analyses of the ASCEND-ND and ASCEND-D trials. Nephrol Dial Transplant. 2023 Jul 31;38(8):1890-1897. doi: 10.1093/ndt/gfac342. PMID: 36565721; PMCID: PMC10387380. View in PubMed

Singh AT, Yen TE, Mothi SS, Waikar SS, Mc Causland FR. Associations of Iron Sucrose and Intradialytic Blood Pressure. Am J Kidney Dis. 2023 Jun;81(6):647-654. doi: 10.1053/j.ajkd.2022.11.007. Epub 2022 Dec 29. PMID: 36587889; PMCID: PMC10205679. View in PubMed

Alostaz M, Correa S, Lundy GS, Waikar SS, Mc Causland FR. Time of hemodialysis and risk of intradialytic hypotension and intradialytic hypertension in maintenance hemodialysis. J Hum Hypertens. 2023 Oct;37(10):880-890. doi: 10.1038/s41371-022-00799-2. Epub 2023 Jan 4. PMID: 36599899. View in PubMed

Mc Causland FR, Hsu JY, Himmelfarb J, Ikizler TA, Raj DS, Mehrotra R, Waikar SS, Kimmel PL, Kliger AS, Dember LM, Charytan DM; Hemodialysis Novel Therapeutics Consortium. Effects of Spironolactone on Arrhythmias in Hemodialysis Patients: Secondary Results of the SPin-D Randomized Controlled Trial. Kidney360. 2023 Apr 1;4(4):e486-e495. doi: 10.34067/KID.0000000000000067. Epub 2023 Feb 10. PMID: 36763641; PMCID: PMC10278797. View in PubMed

Chatur S, Claggett BL, McCausland FR, Rouleau J, Zile MR, Packer M, Pfeffer MA, Lefkowitz M, McMurray JJV, Solomon SD, Vaduganathan M. Variation in Renal Function Following Transition to Sacubitril/Valsartan in Patients With Heart Failure. J Am Coll Cardiol. 2023 Apr 18;81(15):1443-1455. doi: 10.1016/j.jacc.2023.02.009. Epub 2023 Feb 20. PMID: 36812948. View in PubMed

Chatur S, Cunningham JW, Vaduganathan M, Mc Causland FR, Claggett BL, Desai AS, Miao ZM, Jhund PS, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez FA, Shah SJ, Petersson M, Langkilde AM, McMurray JJV, Solomon SD. Renal and blood pressure effects of dapagliflozin in recently hospitalized patients with heart failure with mildly reduced or preserved ejection fraction: Insights from the DELIVER trial. Eur J Heart Fail. 2023 Jul;25(7):1170-1175. doi: 10.1002/ejhf.2915. Epub 2023 Jun 8. PMID: 37212168. View in PubMed

Chatur S, Vaduganathan M, Claggett BL, Mc Causland FR, Desai AS, Jhund PS, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez FA, Shah SJ, Sabatine MS, Kober L, Ponikowski P, Merkely B, Petersson M, Langkilde AM, McMurray JJV, Solomon SD. Dapagliflozin in Patients With Heart Failure and Deterioration in Renal Function. J Am Coll Cardiol. 2023 Nov 7;82(19):1854-1863. doi: 10.1016/j.jacc.2023.08.026. Epub 2023 Aug 25. PMID: 37634707. View in PubMed

Curtis KA, Waikar SS, Mc Causland FR. Higher NT-proBNP levels and the risk of intradialytic hypotension at hemodialysis initiation. Hemodial Int. 2024 Jan;28(1):77-84. doi: 10.1111/hdi.13125. Epub 2023 Oct 24. PMID: 37875429. View in PubMed

Ravi KS, Mavrakanas TA, Charytan DM, Mc Causland FR. The Association of Ejection Fraction With Hospital-Associated Cardiac Arrest and Heart Failure Hospitalization Differs According to Baseline Estimated GFR. Kidney Int Rep. 2023 Aug 25;8(11):2326-2332. doi: 10.1016/j.ekir.2023.08.030. PMID: 38025227; PMCID: PMC10658283. View in PubMed

2022

Liu J, Tio MC, Verma A, Schmidt IM, Ilori TO, Knauf F, Mc Causland FR, Waikar SS. Determinants and Outcomes Associated With Urinary Calcium Excretion in Chronic Kidney Disease. J Clin Endocrinol Metab. 2022 Jan 1;107(1):e281-e292. doi: 10.1210/clinem/dgab574. PMID: 34390334; PMCID: PMC8684460. View in PubMed

Yen TE, Kim A, Benson ME, Ratnaparkhi S, Woolley AE, Mc Causland FR. Serum Sodium, Patient Symptoms, and Clinical Outcomes in Hospitalized Patients with COVID-19. J Prim Care Community Health. 2022 Jan-Dec;13:21501319211067349. doi: 10.1177/21501319211067349. PMID: 34986694; PMCID: PMC8744185. View in PubMed

Mc Causland FR, Lefkowitz MP, Claggett B, Packer M, Senni M, Gori M, Jhund PS, McGrath MM, Rouleau JL, Shi V, Swedberg K, Vaduganathan M, Zannad F, Pfeffer MA, Zile M, McMurray JJV, Solomon SD. Angiotensin-neprilysin inhibition and renal outcomes across the spectrum of ejection fraction in heart failure. Eur J Heart Fail. 2022 Sep;24(9):1591-1598. doi: 10.1002/ejhf.2421. Epub 2022 Jan 18. PMID: 34989105; PMCID: PMC9253196. View in PubMed

Singh AT, Waikar SS, Mc Causland FR. Association of Different Definitions of Intradialytic Hypertension With Long-Term Mortality in Hemodialysis. Hypertension. 2022 Apr;79(4):855-862. doi: 10.1161/HYPERTENSIONAHA.121.18058. Epub 2022 Feb 15. PMID: 35166122; PMCID: PMC8916991. View in PubMed

Dember LM, Hung A, Mehrotra R, Hsu JY, Raj DS, Charytan DM, Mc Causland FR, Regunathan-Shenk R, Landis JR, Kimmel PL, Kliger AS, Himmelfarb J, Ikizler TA; Hemodialysis Novel Therapies Consortium. A randomized controlled pilot trial of anakinra for hemodialysis inflammation. Kidney Int. 2022 Nov;102(5):1178-1187. doi: 10.1016/j.kint.2022.06.022. Epub 2022 Jul 19. PMID: 35863559; PMCID: PMC9588554. View in PubMed

Chatur S, Vaduganathan M, Peikert A, Claggett BL, McCausland FR, Skali H, Pfeffer MA, Beldhuis IE, Kober L, Seferovic P, Lefkowitz M, McMurray JJV, Solomon SD. Longitudinal trajectories in renal function before and after heart failure hospitalization among patients with heart failure with preserved ejection fraction in the PARAGON-HF trial. Eur J Heart Fail. 2022 Oct;24(10):1906-1914. doi: 10.1002/ejhf.2638. Epub 2022 Aug 15. PMID: 35895867; PMCID: PMC10086974. View in PubMed

Ravi KS, Espersen C, Curtis KA, Cunningham JW, Jering KS, Prasad NG, Platz E, Mc Causland FR. Temporal Changes in Electrolytes, Acid-Base, QTc Duration, and Point-of-Care Ultrasound during Inpatient Hemodialysis Sessions. Kidney360. 2022 May 10;3(7):1217-1227. doi: 10.34067/KID.0001652022. PMID: 35919528; PMCID: PMC9337888. View in PubMed

Desai AS, Jhund PS, Claggett BL, Vaduganathan M, Miao ZM, Kondo T, Barkoudah E, Brahimi A, Connolly E, Finn P, Lang NN, Mc Causland FR, McGrath M, Petrie MC, McMurray JJV, Solomon SD. Effect of Dapagliflozin on Cause-Specific Mortality in Patients With Heart Failure Across the Spectrum of Ejection Fraction: A Participant-Level Pooled Analysis of DAPA-HF and DELIVER. JAMA Cardiol. 2022 Dec 1;7(12):1227-1234. doi: 10.1001/jamacardio.2022.3736. PMID: 36189985; PMCID: PMC9531084. View in PubMed

Mc Causland FR, Singh AK, Claggett BL, Carroll K, Wittes J, McMurray JJV, Perkovic V, Snapinn S, Lopes RD, Solomon SD. Daprodustat and On-Treatment Cardiovascular Events in Chronic Kidney Disease. Reply. N Engl J Med. 2022 Dec 29;387(26):2482-2485. doi: 10.1056/NEJMc2208182. PMID: 36577112. View in PubMed

2021

Finnian R Mc Causland, Katherine Scovner Ravi, Katherine A Curtis, Zoé A Kibbelaar, Samuel A P Short, Anika T Singh, Simon Correa, Sushrut S Waikar. A randomized controlled trial of two dialysate sodium concentrations in hospitalized hemodialysis patients. Nephrol Dial Transplant. Nov 18, 2021. doi: 10.1093/ndt/gfab329. PMID: 34792161

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Jering K, McGrath M, Mc Causland F, Claggett B, Cunningham J, Solomon S. Excess mortality in solid organ transplant recipients hospitalized with COVID‐19: A large‐scale comparison of SOT recipients hospitalized with or without COVID‐19. Clin Transplant. 2021. doi:10.1111/ctr.14492 Epub Sept 24 2021. PMID: 34558116.
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Correa S, Guerra-Torres X, Ravi K, Mothi S, Waikar S, Mc Causland F. Risk of Intradialytic Hypotension by Day of the Week in Maintenance Hemodialysis. ASAIO Journal. 2021; Publish Ahead of Print. doi:10.1097/mat.0000000000001576 Epub Sept 7 2021. PMID: 34494985
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Kelly Y, Sharma S, Mothi S, McCausland F, Mendu M, McMahon G et al. Hypocalcemia is associated with hypotension during CRRT: A secondary analysis of the Acute Renal Failure Trial Network Study. Journal of Critical Care.
2021;65:261-267. Epub Jul 15 2021. PMID: 34274834
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Scovner Ravi K, Reeves P, Correa S, Neves J, Waikar S, Mothi S, Waikar S, Mc Causland F. Predialysis serum phosphate and intradialytic hypotension. Hemodialysis International. 2021;. Epub Jul 8 2021. PMID: 34236130
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Singh A, Mothi S, Li P, Sabbisetti V, Waikar S, Mc Causland F. Endothelin-1 and Parameters of Systolic Blood Pressure in Hemodialysis. Am J Hypertens. 2021. doi:10.1093/ajh/hpab104 Epub Jun 30 2021. PMID: 34192305
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Scovner KM, Correa S, Claggett BL, Barrett CD, Waikar SS, Solomon SD, Mc Causland FR. Specific Electrocardiograph Intervals Predict Hospitalization with Atrial Fibrillation in Those with Chronic Kidney Disease. Am J Nephrol. 2021 May 5:1-8. doi: 10.1159/000515670. Epub ahead of print. PMID: 33951623.
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Correa S, Curtis KA, Waikar SS, Mc Causland FR. Serum Myeloperoxidase, Uric Acid, and the Risk of Atrial Fibrillation in Chronic Kidney Disease. Circ Arrhythm Electrophysiol. 2021 Apr;14(4):e009483. doi: 10.1161/CIRCEP.120.009483. Epub 2021 Apr 16. PMID: 33858180.
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Correa S, Mc Causland FR. Leveraging Deep Learning to Improve Safety of Outpatient Hemodialysis. Clin J Am Soc Nephrol. 2021 Mar 8;16(3):343-344. doi: 10.2215/CJN.00450121. Epub 2021 Feb 11. PMID: 33574057; PMCID: PMC8011011.
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Patel RB, Ter Maaten JM, Ferreira JP, Mc Causland FR, Shah SJ, Rossignol P, Solomon SD, Vaduganathan M, Packer M, Thompson A, Stockbridge N, Zannad F. Challenges of Cardio-Kidney Composite Outcomes in Large-Scale Clinical Trials. Circulation. 2021 Mar 2;143(9):949-958. doi: 10.1161/CIRCULATIONAHA.120.04954. Epub 2021 Jan 7. PMID: 33406882; PMCID: PMC7920916.
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Jering KS, Zannad F, Claggett B, Mc Causland FR, Ferreira JP, Desai A, Barkoudah E, McMurray JJV, Pfeffer MA, Solomon SD. Cardiovascular and Renal Outcomes of Mineralocorticoid Receptor Antagonist Use in PARAGON-HF. JACC Heart Fail. 2021 Jan;9(1):13-24. doi: 10.1016/j.jchf.2020.08.014. Epub 2020 Nov 11. PMID: 33189633.
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Endres P, Rosovsky R, Zhao S, Krinsky S, Percy S, Kamal O, Roberts RJ, Lopez N, Sise ME, Steele DJR, Lundquist AL, Rhee EP, Hibbert KA, Hardin CC, Mc Causland FR, Czarnecki PG, Mutter W, Tolkoff-Rubin N, Allegretti AS. Filter clotting with continuous renal replacement therapy in COVID-19. J Thromb Thrombolysis. 2020 Oct 7:1–5. doi: 10.1007/s11239-020-02301-6. Epub ahead of print. PMID: 33026569; PMCID: PMC7539277.

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2021

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2020

Selvaraj S, Claggett BL, Pfeffer MA, Desai AS, Mc Causland FR, McGrath MM, Anand IS, van Veldhuisen DJ, Kober L, Janssens S, Cleland JGF, Pieske B, Rouleau JL, Zile MR, Shi VC, Lefkowitz MP, McMurray JJV, Solomon SD. Serum uric acid, influence of sacubitril-valsartan, and cardiovascular outcomes in heart failure with preserved ejection fraction: PARAGON-HF. Eur J Heart Fail. 2020 Nov;22(11):2093-2101. doi: 10.1002/ejhf.1984. Epub 2020 Sep 30. PMID: 32840930.

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Mc Causland FR, Lefkowitz MP, Claggett B, Anavekar NS, Senni M, Gori M, Jhund PS, McGrath MM, Packer M, Shi V, Van Veldhuisen DJ, Zannad F, Comin-Colet J, Pfeffer MA, McMurray JJV, Solomon SD. Angiotensin Neprilysin Inhibition and Renal Outcomes in Heart Failure With Preserved Ejection Fraction. Circulation. 2020 Sep 29;142(13):1236-1245. doi: 10.1161/CIRCULATIONAHA.120.047643. Epub 2020 Aug 17. PMID: 32845715.
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Mc Causland FR, Tumlin JA, Roy-Chaudhury P, Koplan BA, Costea AI, Kher V, Williamson D, Pokhariyal S, Charytan DM; MiD Investigators and Committees*. Intradialytic Hypotension and Cardiac Arrhythmias in Patients Undergoing Maintenance Hemodialysis: Results from the Monitoring in Dialysis Study. Clin J Am Soc Nephrol. 2020 Jun 8;15(6):805-812. doi: 10.2215/CJN.06810619. Epub 2020 May 7. PMID: 32381584; PMCID: PMC7274298.
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Correa S, Pena-Esparragoza JK, Scovner KM, Mc Causland FR. Predictors of Intradialytic Symptoms: An Analysis of Data From the Hemodialysis Study. Am J Kidney Dis. 2020 Sep;76(3):331-339. doi: 10.1053/j.ajkd.2020.01.004. Epub 2020 Apr 21. PMID: 32331831.
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Neves JS, Correa S, Baeta Baptista R, Bigotte Vieira M, Waikar SS, Mc Causland FR. Association of Prediabetes With CKD Progression and Adverse Cardiovascular Outcomes: An Analysis of the CRIC Study. J Clin Endocrinol Metab. 2020 Apr 1;105(4):e1772–80. doi: 10.1210/clinem/dgaa017. PMID: 31943096; PMCID: PMC7069215.
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Correa S, Pena-Esparragoza JK, Scovner KM, Waikar SS, Mc Causland FR. Myeloperoxidase and the Risk of CKD Progression, Cardiovascular Disease, and Death in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2020 Jul;76(1):32-41. doi: 10.1053/j.ajkd.2019.09.006. Epub 2019 Dec 19. PMID: 31864821.
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Cunningham JW, Sun JL, Mc Causland FR, Ly S, Anstrom KJ, Lindenfeld J, Givertz MM, Stevenson LW, Lakdawala NK. Lower urine sodium predicts longer length of stay in acute heart failure patients: Insights from the ROSE AHF trial. Clin Cardiol. 2020 Jan;43(1):43-49. doi: 10.1002/clc.23286. Epub 2019 Nov 12. PMID: 31721249; PMCID: PMC6954375.
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Vuddanda VLK, Turagam MK, Umale NA, Shah Z, Lakkireddy DR, Bartus K, McCausland FR, Velagapudi P, Mansour M, Heist EK. Incidence and causes of in-hospital outcomes and 30-day readmissions after percutaneous left atrial appendage closure: A US nationwide retrospective cohort study using claims data. Heart Rhythm. 2020 Mar;17(3):374-382. doi: 10.1016/j.hrthm.2019.09.018. Epub 2019 Sep 17. PMID: 31539630.
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2019

Leitão L, Soares-Dos-Reis R, Neves JS, Baptista RB, Bigotte Vieira M, Mc Causland FR. Intensive Blood Pressure Treatment Reduced Stroke Risk in Patients With Albuminuria in the SPRINT Trial. Stroke. 2019 Oct 22:STROKEAHA119026316. doi: 10.1161/STROKEAHA.119.026316. [Epub ahead of print] PubMed PMID: 31637971.
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Mc Causland FR, Claggett B, Sabbisetti VS, Jarolim P, Waikar SS. Hypertonic Mannitol for the Prevention of Intradialytic Hypotension: A Randomized Controlled Trial. Am J Kidney Dis. 2019 Oct;74(4):483-490. doi: 10.1053/j.ajkd.2019.03.415. Epub 2019 Apr 27. PubMed PMID: 31040088; PubMed Central PMCID: PMC6756938.
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Opotowsky AR, Carazo M, Singh MN, Dimopoulos K, Cardona-Estrada DA, Elantably A, Waikar SS, Mc Causland FR, Veldtman G, Grewal J, Gray C, Loukas BN, Rajpal S. Creatinine versus cystatin C to estimate glomerular filtration rate in adults with congenital heart disease: Results of the Boston Adult Congenital Heart Disease Biobank. Am Heart J. 2019 Aug;214:142-155. doi: 10.1016/j.ahj.2019.04.018. Epub 2019 May 22. PubMed PMID: 31203159.
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Vieira MB, Neves JS, Leitão L, Baptista RB, Magriço R, Dias CV, Oliveira A, Carvalho D, Mc Causland FR. Impaired Fasting Glucose and Chronic Kidney Disease, Albuminuria, or Worsening Kidney Function: a Secondary Analysis of the SPRINT. J Clin Endocrinol Metab. 2019 May 7. pii: jc.2019-00073. doi: 10.1210/jc.2019-00073. [Epub ahead of print] PubMed PMID: 31063197; PubMed Central PMCID: PMC6676073.
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Desai AS, Mc Causland FR. Urinary Sodium as a Heart Failure Biomarker: More Complicated Than it Seems. JACC Heart Fail. 2019 May;7(5):415-417. doi: 10.1016/j.jchf.2019.03.002. PubMed PMID: 31047022.
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Mc Causland FR, Claggett B, Burdmann EA, Chertow GM, Cooper ME, Eckardt KU, Ivanovich P, Levey AS, Lewis EF, McGill JB, McMurray JJV, Parfrey P, Parving HH, Remuzzi G, Singh AK, Solomon SD, Toto RD, Pfeffer MA. Treatment of Anemia With Darbepoetin Prior to Dialysis Initiation and Clinical Outcomes: Analyses From the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT). Am J Kidney Dis. 2019 Mar;73(3):309-315. doi: 10.1053/j.ajkd.2018.10.006. Epub 2018 Dec 19. PubMed PMID: 30578152; PubMed Central PMCID: PMC6420804.
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Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Boerger EAS, Mc Causland FR, Eisenga MF, Singh K, Babitt JL, Kellum JA, Palevsky PM, Christov M, Waikar SS. Iron, Hepcidin, and Death in Human AKI. J Am Soc Nephrol. 2019 Mar;30(3):493-504. doi: 10.1681/ASN.2018100979. Epub 2019 Feb 8. PubMed PMID: 30737269; PubMed Central PMCID: PMC6405140.
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2018

Mc Causland FR, Pfeffer MA. Implantable cardioverter defibrillators in chronic kidney disease. Nat Rev Nephrol. 2018 Jun;14(6):357-358. doi: 10.1038/s41581-018 0007-5. PubMed PMID: 29651098.
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Leaf DE, Siew ED, Eisenga MF, Singh K, Mc Causland FR, Srivastava A, Ikizler TA, Ware LB, Ginde AA, Kellum JA, Palevsky PM, Wolf M, Waikar SS. Fibroblast Growth Factor 23 Associates with Death in Critically Ill Patients. Clin J Am Soc Nephrol. 2018 Apr 6;13(4):531-541. doi: 10.2215/CJN.10810917. Epub 2018 Mar 8. PubMed PMID: 29519954; PubMed Central PMCID: PMC5969465.
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Rajpal S, Alshawabkeh L, Almaddah N, Joyce CM, Shafer K, Gurvitz M, Waikar SS, Mc Causland FR, Landzberg MJ, Opotowsky AR. Association of Albuminuria With Major Adverse Outcomes in Adults With Congenital Heart Disease: Results From the Boston Adult Congenital Heart Biobank. JAMA Cardiol. 2018 Apr 1;3(4):308-316. doi: 10.1001/jamacardio.2018.0125. PubMed PMID: 29541749; PubMed Central PMCID: PMC5875351.
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Reeves PB, Mc Causland FR. Mechanisms, Clinical Implications, and Treatment of Intradialytic Hypotension. Clin J Am Soc Nephrol. 2018 Aug 7;13(8):1297-1303. doi: 10.2215/CJN.12141017. Epub 2018 Feb 26. Review. PubMed PMID: 29483138; PubMed Central PMCID: PMC6086712.
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2017

Singh AT, Mc Causland FR. Osmolality and blood pressure stability during hemodialysis. Semin Dial. 2017 Nov;30(6):509-517. doi: 10.1111/sdi.12629. Epub 2017 Jul 9. Review. PubMed PMID: 28691402; PubMed Central PMCID: PMC5931915.
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Opotowsky AR, Baraona FR, Mc Causland FR, Loukas B, Landzberg E, Landzberg MJ, Sabbisetti V, Waikar SS. Estimated glomerular filtration rate and urine biomarkers in patients with single-ventricle Fontan circulation. Heart. 2017 Mar;103(6):434-442. doi: 10.1136/heartjnl-2016-309729. Epub 2016 Sep 26. PubMed PMID: 27670967; PubMed Central PMCID: PMC5500305.
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Flythe JE, Mc Causland FR. Dialysate Sodium: Rationale for Evolution over Time. Semin Dial. 2017 Mar;30(2):99-111. doi: 10.1111/sdi.12570. Epub 2017 Jan 8. Review. PubMed PMID: 28066913; PubMed Central PMCID: PMC5334180.
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Mc Causland FR, Claggett B, Pfeffer MA, Burdmann EA, Eckardt KU, Levey AS, McMurray JJV, Remuzzi G, Singh AK, Solomon SD, Toto RD, Parfrey P. Change in Hemoglobin Trajectory and Darbepoetin Dose Approaching End-Stage Renal Disease: Data from the Trial to Reduce Cardiovascular Events with Aranesp Therapy Trial. Am J Nephrol. 2017;46(6):488-497. doi: 10.1159/000485326. Epub 2017 Dec 14. PubMed PMID: 29241199; PubMed Central PMCID: PMC5764793.
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2016

Mc Causland FR, Claggett B, Burdmann EA, Eckardt KU, Kewalramani R, Levey AS, McMurray JJ, Parfrey P, Remuzzi G, Singh AK, Solomon SD, Toto RD, Pfeffer MA. C-Reactive Protein and Risk of ESRD: Results From the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT). Am J Kidney Dis. 2016 Dec;68(6):873-881. doi: 10.1053/j.ajkd.2016.07.022. Epub 2016 Sep 16. PubMed PMID: 27646425; PubMed Central PMCID: PMC5123931.
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2015

Mc Causland FR, Asafu-Adjei J, Betensky RA, Palevsky PM, Waikar SS. Comparison of Urine Output among Patients Treated with More Intensive Versus Less Intensive RRT: Results from the Acute Renal Failure Trial Network Study. Clin J Am Soc Nephrol. 2016 Aug 8;11(8):1335-42. doi: 10.2215/CJN.10991015. Epub 2016 Jul 22. PubMed PMID: 27449661; PubMed Central PMCID: PMC4974887.
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Mc Causland FR, Waikar SS. Association of Predialysis Calculated Plasma Osmolarity With Intradialytic Blood Pressure Decline. Am J Kidney Dis. 2015 Sep;66(3):499-506. doi: 10.1053/j.ajkd.2015.03.028. Epub 2015 May 12. PubMed PMID: 25975966; PubMed Central PMCID: PMC4782777.
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2014 & earlier

Mc Causland FR, Wright J, Waikar SS. Association of serum sodium with morbidity and mortality in hospitalized patients undergoing major orthopedic surgery. J Hosp Med. 2014 May;9(5):297-302. doi: 10.1002/jhm.2168. Epub 2014 Feb 1. PubMed PMID: 24523043; PubMed Central PMCID: PMC4815900.
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Mc Causland FR, McMullan CJ, Sacks FM, Forman JP. Race, plasma renin activity, and morning blood pressure surge–results from the Dietary Approaches to Stop Hypertension trial. Am J Hypertens. 2014 Apr;27(4):530-6. doi: 10.1093/ajh/hpt031. Epub 2013 Mar 8. PubMed PMID: 23475701; PubMed Central PMCID: PMC4014854.
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Mc Causland FR, Waikar SS. Optimal dialysate sodium-what is the evidence? Semin Dial. 2014 Mar;27(2):128-34. doi: 10.1111/sdi.12182. Epub 2014 Jan 23. Review. PubMed PMID: 24450281; PubMed Central PMCID: PMC5500308.
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Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, Lawler LA, Christie JD, Meyer NJ, Mc Causland FR, Waikar SS, Waxman AB, Chung RT, Bueno R, Rosas IO, Fredenburgh LE, Baron RM, Christiani DC, Hunninghake GM, Choi AM. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med. 2013 Dec;10(12):e1001577; discussion e1001577. doi: 10.1371/journal.pmed.1001577. Epub 2013 Dec 31. PubMed PMID: 24391478; PubMed Central PMCID: PMC3876981.
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Mc Causland FR, Waikar SS, Brunelli SM. The relevance of dietary sodium in hemodialysis. Nephrol Dial Transplant. 2013 Apr;28(4):797-802. doi: 10.1093/ndt/gfs452. Epub 2012 Nov 4. Review. PubMed PMID: 23129821; PubMed Central PMCID: PMC3716331.
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Mc Causland FR, Brunelli SM, Waikar SS. Dialysis dose and intradialytic hypotension: results from the HEMO study. Am J Nephrol. 2013;38(5):388-96. doi: 10.1159/000355958. Epub 2013 Oct 26. PubMed PMID: 24192428; PubMed Central PMCID: PMC3904183.
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Mc Causland FR, Brunelli SM, Waikar SS. Association of smoking with cardiovascular and infection-related morbidity and mortality in chronic hemodialysis. Clin J Am Soc Nephrol. 2012 Nov;7(11):1827-35. doi: 10.2215/CJN.03880412. Epub 2012 Aug 23. PubMed PMID: 22917700; PubMed Central PMCID: PMC3488948.
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Mc Causland FR, Waikar SS, Brunelli SM. Increased dietary sodium is independently associated with greater mortality among prevalent hemodialysis patients. Kidney Int. 2012 Jul;82(2):204-11. doi: 10.1038/ki.2012.42. Epub 2012 Mar 14. PubMed PMID: 22418981; PubMed Central PMCID: PMC3779624.
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Mc Causland FR, Brunelli SM, Waikar SS. Dialysate sodium, serum sodium and mortality in maintenance hemodialysis. Nephrol Dial Transplant. 2012 Apr;27(4):1613-8. doi: 10.1093/ndt/gfr497. Epub 2011 Sep 2. PubMed PMID: 21891777; PubMed Central PMCID: PMC3471551.
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Mc Causland FR, Prior LM, Heher E, Waikar SS. Preservation of blood pressure stability with hypertonic mannitol during hemodialysis initiation. Am J Nephrol. 2012;36(2):168-74. doi: 10.1159/000341273. Epub 2012 Jul 26. PubMed PMID: 22846598; PubMed Central PMCID: PMC3779621.
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Mc Causland FR, Tilley BS, Waikar SS. Dialysate sodium and the milieu intérieur. Clin J Am Soc Nephrol. 2012 Jan;7(1):5-7. doi: 10.2215/CJN.12101111. Epub 2011 Dec 15. PubMed PMID: 22173861.
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Mc Causland FR, Niedermaier S, Bijol V, Rennke HG, Choi ME, Forman JP. Lyme disease-associated glomerulonephritis. Nephrol Dial Transplant. 2011 Sep;26(9):3054-6. doi: 10.1093/ndt/gfr335. Epub 2011 Jul 12. PubMed PMID: 21750163.
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